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Therapeutic approaches targeting glutamate-glutamine metabolism in malignant gliomas. Summarization of some putative targets and drugs (red) in glioma cells: inhibition of glutaminase (GLS); inhibition of glutamine synthetase (GS); xc– inhibition; GLT-1 overexpression; GLAST silencing. White arrows represent the transporters’ expression level in gliomas: down arrow corresponds to lower expression; up arrow is overexpression.
