Table 4.

Results of the Cox multivariate analysis (p < 0.0001).

Variable		Haz. Ratio	p > z	95% Conf. Interval
Age at diagnosis		1.02	0.02 1	1.00−1.04
		1.01 2	0.2	0.99−1.04
Gender		0.62	0.1	0.33−1.14
		0.65	0.2	0.32−1.33
Altitude of Residence		1.00	0.004	1.00−1.00
		1.00	0.03	1.00−1.00
Anatomical Site		1.13	0.3	0.90−1.40
		1.01	0.9	0.77−1.32
Geographic area		1.13	0.5	0.69−1.87
		1.13	0.8	0.42−3.01
TRPM1		0.76	0.5	0.36−1.61
		0.72	0.5	0.29−1.80
TYRP1		2.43	0.01	1.24−4.77
		2.51	0.02	1.15−5.48
PDL1 (CD274)		0.71	0.3	0.37−1.35
		0.49	0.06	0.23−1.01
CD2		0.75	0.4	0.39−1.42
		0.94	0.9	0.46−1.93
MITF		0.51	0.04	0.27−0.97
		0.98	0.9	0.44−2.19
HIF1A		1.15	0.6	0.66−2.00
		1.39	0.4	0.69−2.75
miR-150-5p		0.96	0.9	0.48−1.93
		0.62	0.3	0.27−1.42
miR-155-5p		0.95	0.9	0.50−1.79
		0.86	0.7	0.41−1.80
miR-204-5p		0.87	0.7	0.48−1.59
		1.08	0.8	0.53−2.19
miR-211-5p		0.99	1	0.44−2.25
		0.58	0.3	0.21−1.60
Mutational Status		1.98	<0.001	1.40−2.25
		1.55	0.04	1.01−2.39
Stage at diagnosis	II	0.67	0.4	0.25−1.81
		0.95	0.9	0.27−3.31
	III	1.38	0.5	0.49−3.94
		1.87	0.4	0.48−7.32
	IV	9.89	<0.001	2.76−35.5
		11.1	0.008	1.88−65.8
Ulceration		1.3	0.4	0.72−2.34
		1.5	0.3	0.73−2.99
phtest p = 0.3
phtest p = 0.1

¹: Underlined p highlights statistical significance; ²: In italics are reported the values of the Cox regression by exclusion of patients from Innsbruck and its land.