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Formation and growth of ovarian cancer (OC) cell spheroids in standard plastic tissue culture plates and marine collagen-based (MC-B) hydrogels. (A) Phase contrast microscopy images showing OC cell (A2780, ES-2, and R182 cells) spheroids on culture days 1, 3, 5, 8, 10, and 12 (original magnification ×100). (B) Diameters of the OC cell spheroids are depicted in a bar graph. *** p < 0.001 vs. those on day 1. Scale bars = 50 μm.
