Table 3.
Impact of geraniol pretreatment on GSH levels and mitochondrial antioxidant enzymes activities in isoproterenol-induced myocardial infarction.
| Antioxidants | Control | Geraniol | ISO | ISO + Geraniol (100 mg/kg) | ISO + Geraniol (200 mg/kg) |
|---|---|---|---|---|---|
| GSH (nmol/mg protein) | 7.28 ± 0.24 | 7.45 ± 0.12 | 3.66 ± 0.19 € | 5.49 ± 0.19 ҂ | 6.24 ± 0.26 ҂* |
| SOD (micromol H2O2/min/mg protein) | 124.14 ± 6.25 | 128.16 ± 5.46 | 65.43 ± 8.4 € | 89.49 ± 4.60 ҂ | 95.19 ± 6.10 ҂* |
| CAT (micromol H2O2/min/mg protein) | 1.49 ± 0.06 | 1.46 ± 0.08 | 0.64 ± 0.06 € | 1.02 ± 0.05 ҂ | 1.17 ± 0.03 ҂ |
| GPx (µg of GSH utilized/min/mg protein) | 19.63 ± 1.4 | 20.25 ± 2.1 | 7.46 ± 1.51 € | 12.10 ± 1.24 ҂ | 15.54 ± 2.43 ҂* |
| GST (nmol/mg protein) | 524.2 ± 15.86 | 532.41 ± 6.71 | 382.5 ± 12.93 € | 457.11 ± 4.24 ҂ | 483 ± 16.48 ҂* |
GSH: glutathione; SOD: superoxide dismutase; CAT: catalase; GPx, glutathione peroxidase; GST: glutathione-S-transferase; All values were stated as mean ± SD (n = 6). €, p < 0.05 compared to the normal group; ҂, p < 0.05 compared to the ISO-induced MI group; *, p < 0.05 compared to the ISO + geraniol (100 mg/kg) group. Comparisons done using one-way ANOVA followed by Tukey-Kramer post-hoc test.