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. 2020 Oct 8;12(10):2884. doi: 10.3390/cancers12102884

Figure 7.

Figure 7

Breast cancer cells induce neutrophils to secrete pro-tumor factors, which aids tumor growth and metastasis. The pictorial diagram showing breast cancer cells enhances pro-tumor factors in neutrophils, which supports tumor growth and metastasis. Breast cancer cells increase the secretion of cytokines and chemokines as well as NET formation in neutrophils. In contrast, chemotherapy-resistant cells further enhanced neutrophil survival and secretion of MMP9, which can result in higher metastasis of chemotherapy-resistant cells.