Figure 3.

Macrophages in BCC have more of a pro-inflammatory genotype, regardless of responder status. (A,B) Dimensionality reduction of the macrophage subsets of melanoma (A) and BCC (B). (C,D) Percentage of responders/non-responders in pre/post-treatment per macrophage cluster in melanoma (C) and BCC (D). (E,F) Average expression of anti- and pro-inflammatory genes by cluster of macrophages in melanoma (E) and BCC (F). (G,H) Psuedotime of macrophage clusters in melanoma (G) and BCC (H). Each psuedotime node is qualitatively colored by a normalized expression of the anti-inflammation score. The melanoma psuedotime correlates well with the percent of non-responders post-treatment, whereas the BCC psuedotime does not.