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The silencing of APEX1, RTEL1, and COPS6 impairs acute myeloid leukemia (AML) cell growth. Using CRISPR or RNAi screening publicly available data (Dependency Map data, Broad Institute, www.depmap.org), dependency scores of APEX1, RTEL1, and COPS6 underline their specific importance for AML cell survival compared to all cell lines tested.
