Table 4.

DNA repair score and NPM1/FLT3 mutational status combination to establish a global prognosis score in CN-AML. Patients were classified according to DNA repair score risk group (I, II or III) and NPM1/FLT3 mutational status.

		Classification According to DNA Repair Score
		Group I 0 point	Group II 1 point	Group III 2 points
NPM1 and FLT3 mutational status	NPM1+ and FLT3-ITD- 0 point	0	1	2
	NPM1+ and FLT3-ITD+ or NPM1- and FLT3-ITD- 1 point	1	2	3
	NPM1- and FLT3-ITD+ 2 points	2	3	4

Patients with NPM1 mutation or FLT3-ITD are respectively designated by NPM1+ and FLT3-ITD+. Patients without NPM1 mutation or FLT3-ITD are respectively designated by NPM1- and FLT3-ITD-. Points were attributed as described in the table. Patients with 0 or 1 point were grouped in group A (green), patients with 2 points were grouped in group B (yellow), and patients with 3 or 4 points were grouped in group C (red). ITD: internal tandem duplication.