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Loss of Parp1 reduces pituitary adenoma number and size in Rb+/− mice. At 8 months of age, pituitary tumours not only occurred in a smaller percentage of Parp1−/− Rb+/− mice than Parp1+/+ Rb+/− mice, but also the presence of Parp1 was associated with higher tumour volume (* p < 0.05). Scale = 2 mm. Representative images of pituitary tumours.
