Figure 5.

Frailty assessment in vitamin D treated mice. Frailty assessment for 125IU (orange), 1000IU (black), and 8000IU (green) mice is based upon the Fried et al. physical frailty scale [17], in which mice exhibiting three or more assessments below cohort-determined cutoff levels for unexpected weight loss, grip strength, endurance, activity levels, and gait speed were considered frail, and prefrail if below cutoff in 1 or 2 parameters. Scores were determined at baseline, “B” and endpoint “E”. Statistical significance is indicated by “*” p < 0.05, “**” p < 0.01, and “ns” indicating non-significance.