Figure 1.
Phosphate homeostasis. (A) The acute response and (B) the chronic response to increases in phosphate intake. (C) The acute response and (D) the chronic response to decreases in phosphate intake. Details are provided in the text. Numbers show hypothetical shifts of phosphorus between body compartments for a 70 kg adult based on [28]. GI, gastrointestinal. ICF, intracellular fluid. PTH, parathyroid hormone. 1,25(OH)2D, 1,25-dihydroxycholecalciferol (calcitriol). FGF23, fibroblast growth factor 23. Pi, inorganic phosphate. dL, deciliter. mg, milligram. SI conversion: 1 mg phosphorus = 0.32 mmol phosphorus. Adapted from [29].