Table A1.
White matter regions from the ICBM-DTI-81 White Matter Atlas for which significant decreased AD values were found in CM compared to EM including the time from onset of CM as a covariate.
| White Matter Region | Minimum p-Value (FWE-Corrected) | Volume (mm3) | MNI Peak Coordinate (mm), (x,y,z) |
|---|---|---|---|
| Middle cerebellar peduncle | 0.023 | 1295 | (−20,−50,−32) |
| Superior cerebellar peduncle R/L | 0.028/0.030 | 101/115 | (5,−28,−19)/(−4,−28,−19) |
| Inferior cerebellar peduncle L | 0.035 | 46 | (−10,−50,−25) |
| Superior longitudinal fasciculus R | 0.033 | 720 | (32,−4,20) |
| Splenium of corpus callosum | 0.042 | 32 | (18,−49,27) |
| Superior corona radiata R/L | 0.030/0.032 | 335/136 | (28,−15,19)/(−27,−11,20) |
| Posterior corona radiata R | 0.035 | 83 | (28,−34,19) |
| External capsule R/L | 0.033/0.031 | 127/171 | (30,−10,14)/(−28,−10,18) |
| Posterior limb of internal capsule R/L | 0.029/0.032 | 301/281 | (26,−17,13)/(−27,−17,17) |
| Retrolenticular part of internal capsule R/L | 0.031/0.032 | 473/59 | (30,−29,7)/(−25,−23,12) |
| Sagittal stratum R | 0.034 | 150 | (38,−28,−4) |
| Posterior thalamic radiation R | 0.034 | 51 | (30,−39,16) |
| Cerebral peduncle R/L | 0.028/0.031 | 207/258 | (10,−28,−16)/(−9,−20,−20) |
| Corticospinal tract R/L | 0.030/0.031 | 105/125 | (11,−22,−22)/(−7,−18,−22) |
| Pontine crossing tract | 0.030 | 56 | (4,−26,−24) |
| Fornix (cres) R | 0.037 | 46 | (35,−12,−14) |
FWE = Family-wise error; L = left; R = right. The column volume represents the volume from the atlas region with significant results. No regions with a volume equal or lower than 30 mm3 were included in this table.