Figure 16.

Complex structures of MoMuLV and RSV NC bound to the recognition elements in their respective packaging signals (reported in [66] and [112], respectively). (A) MoMuLV NC-UCUG complex structure (PDB ID: 1U6P). SL-B, SL-C, and SL-D are colored in red, blue, and gold, respectively. The UCUG linker and binding site is colored gray with G309 in magenta. The zinc knuckle domain of the MoMuLV NC is shown in green, with the black dashes representing the coordination of Zn. (B) The direct interaction between the MoMuLV NC and G309. Hydrogen bonds are shown as yellow dashes and the gray spheres represent hydrophobic interactions. (C) RSV NC bound to the µΨ packaging signal (PDB ID: 2IHX). The O3-stem, SL-A, AUG-3 linker, SL-B, and SL-C are colored gray, purple, pink, gold, and red, respectively. The N-terminal zinc knuckle, linker residues, and C-terminal zinc knuckle are colored blue, green, and orange, respectively. G218 nucleobase is colored green. A168 and A197 nucleobases are colored cyan. (D) The N-terminal zinc knuckle of the RSV NC interacting with G218. (E) The C-terminal zinc knuckle interacting with A168 and A197. Salt bridge interactions are depicted as cyan-colored dashes.