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Small molecule inhibitor of HIV-1 genome packaging. (A) Structure of packaging inhibitor NSC. (B) Binding sites of NSC in the Ψ-hairpin of the HIV-1 packaging signal. (C) NSC treatment reduces HIV-1 selective genome packaging. Asterisks represent statistically significant from wild-type (WT) by Student’s t test, p < 0.05. Panel (C) reproduced from [389], with permission.
