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. 2020 Sep 28;10(10):385. doi: 10.3390/metabo10100385

Figure 2.

Figure 2

Hepatic lipid accumulation is reduced in neuron-specific LPL KD mice. (A) Hematoxylin and eosin stained liver of 12 months WT (LPLflox) and LPL KD (NEXCreLPLflox) mice. (B) Hepatic triglyceride (TG) concentration in LPL KD (black bars) compared to WT mice (white bars) at 6, 12, and 18 months. (C) Hepatic mono-unsaturated fatty acid (MUFA) concentration reduced in LPL KD mice compared to WT mice at 6, 12, and 18 months. (D) Fast protein liquid chromatography (FPLC) fractionation of lipoproteins from plasma of LPL KD and WT mice at 18 months. (E) Cholesterol content of lipoprotein fractions at 18 months. (F,G) Relative gene expression of SCD1 and FADS2 at 6, 12, and 18 months. (* = p < 0.05 vs. aged-matched WT controls).