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. 2020 Sep 28;10(10):385. doi: 10.3390/metabo10100385

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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LPL depletion in neurons of the paraventricular nucleus of the hypothalamus (PVN) results in altered neuronal metabolism. (A) LPL was depleted in the PVN of LPL^flox mice by the delivery of AAV8-CaMKIIa-GFP-Cre, whereas AAV8-CaMKIIa-GFP was administered to control mice. (B) Representative images of nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD) fluorescence lifetime imaging microscopy (FLIM) maps from images of the PVN in control versus LPL KD Mice. (C) Phasor plots showing the shift in metabolic trajectory with changing lifetime for NADH and FAD. (D) Increased ratio of free/bound NADH in LPL KD PVN neurons. (E) Increased free FAD fraction in LPL KD PVN neurons. (* = p < 0.05 vs WT, **** = p < 0.0001 vs. WT).