Table 5.
Lists of genes involved in the PPI network.
| Gene | Function of the Encoding Proteins |
|---|---|
| OXTR | Receptor for oxytocin associated with social recognition and emotion processing |
| MTHFR | Influences susceptibility to neural tube defect by changing folate metabolism |
| RELN | Control cell positioning and neural migration during brain development |
| DRD3 | D3 subtype of the five dopamine receptors; localized to the limbic areas of the brain |
| MNT | Protein member of the Myc/Max/Mad network; transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth |
| OPCML | Member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins; localized in the plasma membrane; accessory role in opioid receptor function |
| PC | Pyruvate carboxylase; gluconeogenesis, lipogenesis, insulin secretion and synthesis of neurotransmitter glutamate |
| ERBB4 | Tyr protein kinase family and the epidermal growth factor receptor subfamily; binds to and is activated by neuregulins, and induces mitogenesis and differentiation |
| OR2M4 | Members of a large family of GPCR; olfactory receptors initiating a neuronal response that triggers the perception of a smell |
| BCAS1 | Oncogene; highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. |
| CYP24A1 | Cytochrome P450 superfamily of enzymes; drug metabolism and synthesis of cholesterol, steroids and other lipids |
| TMEM132B | The function remains poorly understood despite their mutations associated with non-syndromic hearing loss, panic disorder, and cancer |
| KRR1 | Nucleolar protein; 18S rRNA synthesis and 40S ribosomal assembly |
| HAT1 | Type B histone acetyltransferase; rapid acetylation of newly synthesized cytoplasmic histones; replication-dependent chromatin assembly |
| SGSM2 | GTPase activator; regulators of membrane trafficking |
| EXT1 | Endoplasmic reticulum-resident type II transmembrane glycosyltransferase; involved in the chain elongation step of heparan sulfate biosynthesis |
| OR2T33 | Members of a large family of GPCR; share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors |
| TAF1C | Binds to the core promoter of ribosomal RNA genes to position the polymerase properly; acts as a channel for regulatory signals |
| HDAC4 | Class II of the histone deacetylase/acuc/apha family; represses transcription when tethered to a promoter |
| MEGF10 | Member of the multiple epidermal growth factor-like domains protein family; cell adhesion, motility and proliferation; critical mediator of apoptotic cell phagocytosis; amyloid-beta peptide uptake in brain |
| NFKB2 | Subunit of the transcription factor complex nuclear factor-kappa-B; central activator of genes involved in inflammation and immune function |
| BNC2 | Conserved zinc finger protein; skin color saturation |
| NMB | Member of the bombesin-like family of neuropeptides; negatively regulate eating behavior; regulate colonic smooth muscle contraction |
| HPS6 | Organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes |
| ELOVL3 | GNS1/SUR4 family; elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides |
| PITX3 | Member of the RIEG/PITX homeobox family; transcription factors; lens formation during eye development |
| NAALADL2 | Not well-known, but diseases associated with NAALADL2 include Chromosome 6Pter-P24 Deletion Syndrome and Cornelia De Lange Syndrome. |
| MACROD2 | Deacetylase removing ADP-ribose from mono-ADP-ribosylated proteins; translocate from the nucleus to the cytoplasm upon DNA damage |
| CUEDC2 | CUE domain-containing protein; down-regulate ESR1 protein levels through progesterone-induced and degradation of receptors |
| FBXL15 | Substrate recognition component of SCF E3 ubiquitin-protein ligase complex; mediates the ubiquitination and subsequent proteasomal degradation of SMURF1 |
| EXOC4 | Component of the exocyst complex; targeting exocytic vesicles to specific docking sites on the plasma membrane |
| NOLC1 | Nucleolar protein; act as a regulator of RNA polymerase I; neural crest specification; nucleologenesis |
| PPRC1 | Similar to PPAR-gamma coactivator 1; activate mitochondrial biogenesis through NRF1 in response to proliferative signals |
| SEC11A | Member of the peptidase S26B family; subunit of the signal peptidase complex; cell migration and invasion, gastric cancer and lymph node metastasis |
Abbreviations: OXTR, Oxytocin Receptor; MTHFR, Methylene tetrahydrofolate reductase; RELN, reelin, DRD3, Dopamine Receptor D3; MNT, Myc-associated factor X (MAX) Network Transcriptional Repressor; OPCML, opioid binding protein/cell adhesion molecule-like; PC, Pyruvate carboxylase; ERBB4, Erb-B2 Receptor Tyrosine Kinase 4; OR2M4, olfactory receptor family 2 subfamily M member 4; GPCR, G protein-coupled receptor; BCAS1, Breast Carcinoma Amplified Sequence 1; CYP24A1, Cytochrome P450 Family 24 Subfamily A Member 1; TMEM132B, transmembrane protein 132B; KRR1, KRR1 small subunit processome component homolog; HAT1, histone acetyltransferase 1; SGSM2, small G protein signaling modulator 2; EXT1, Exostosin-1; OR2T33, Olfactory receptor 2T33; TAF1C, TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit C; HDAC4, Histone deacetylase 4; MEGF10, Multiple Epidermal Growth Factor Like Domains 10; NFKB2, Nuclear Factor Kappa B Subunit 2; BNC2, basonuclin-2; NMB, Neuromedin B; HPS6, Hermansky–Pudlak syndrome 6; ELOVL3, Elongation Of Very Long Chain Fatty Acids Protein 3, PITX3, Pituitary homeobox 3; NAALADL2, N-Acetylated Alpha-Linked Acidic Dipeptidase Like 2; MACROD2, Mono-ADP Ribosylhydrolase 2; CUEDC2, CUE domain containing 2; FBXL15, F-Box And Leucine Rich Repeat Protein 15; EXOC4, Exocyst Complex Component 4; NOLC1, Nucleolar And Coiled-Body Phosphoprotein 1; PPRC1, peroxisome proliferator-activated receptor gamma, coactivator-related 1; SEC11A, SEC11 Homolog A, Signal Peptidase Complex Subunit.