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. 2020 Oct 8;9(10):328. doi: 10.3390/biology9100328

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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A 3D dumbbell model designed to study fibroblast-guided cancer cell migration. (A) Fibroblast and CaKi-1 cells were seeded as independent droplets separated by a 1 mm Matrigel causeway. Upon forming a meshwork of vessel-like structures, fibroblast cells swiftly migrated across the causeway to infiltrate and eventually encapsulate the entire CaKi-1 cell population within a spheroid. (B) Enlarged view of the fibroblast invasion front on day 6. Note that the cancer cells are pre-labelled with RFP.