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. 2020 Sep 28;12(10):620. doi: 10.3390/toxins12100620

Figure 2.

Figure 2

Time course of the relieving effects of ST36 treatment with bee venom acupuncture (BVA) on paclitaxel-induced cold (A) and mechanical (B) allodynia in mice. Mice were divided arbitrarily into four groups. “0.25,” “1.0,” and “2.5 mg/kg” referred to the doses of BV injected at ST36. (C,D) illustrated the analgesic effects of 1.0 mg/kg of BVA at ST36 (BVA-ST36) versus at the neck, a different body area (BVA-Neck), on cold and mechanical allodynia. Behavioral sensitivity was assessed four times; just prior to the injection of BV and resumed at 60-min intervals for 3 h after treatment (on the timeline: 0, 60, 120, and 180, respectively). Data are expressed as mean ± S.E.M.; * p < 0.05, ** p < 0.01, *** p < 0.001, vs. control (PBS; A and B); * p < 0.05, ** p < 0.01, vs. BVA-Neck group (C and D) by Bonferroni post-test after two-way ANOVA.