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. 2020 Sep 27;9(10):924. doi: 10.3390/antiox9100924

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Magnolol (MG) inhibited the activation of NLRP3 inflammasome in PA-induced steatosis and lipopolysaccharide (LPS)-challenged HepG2 cells. (A) IL-1β protein levels in the supernatant fraction of steatotic cells; (B) representative Western blot and densitometry analysis of NLRP3, ASC, caspase1 p20, and procaspase1 p50 in steatotic cells; (C) IL-1β protein levels in the supernatant fraction of LPS-challenged cells; (D) representative Western blot and densitometry analysis of caspase1 p20, procaspase1 p50, IL-6, and TNF-α in LPS-challenged cells; (E) representative Western blot and densitometry analysis of autophagy-related markers LC3B, ATG7, p62/SQSTM1, and mTOR in steatotic cells. Data are expressed as mean ± SEM, n = 4. * p < 0.05 vs. Ctrl; ⁺ p < 0.05 vs. MG; ^# p < 0.05 vs. PA; ^& p < 0.05 vs. LPS.

Magnolol (MG) inhibited the activation of NLRP3 inflammasome in PA-induced steatosis and lipopolysaccharide (LPS)-challenged HepG2 cells. (A) IL-1β protein levels in the supernatant fraction of steatotic cells; (B) representative Western blot and densitometry analysis of NLRP3, ASC, caspase1 p20, and procaspase1 p50 in steatotic cells; (C) IL-1β protein levels in the supernatant fraction of LPS-challenged cells; (D) representative Western blot and densitometry analysis of caspase1 p20, procaspase1 p50, IL-6, and TNF-α in LPS-challenged cells; (E) representative Western blot and densitometry analysis of autophagy-related markers LC3B, ATG7, p62/SQSTM1, and mTOR in steatotic cells. Data are expressed as mean ± SEM, n = 4. * p < 0.05 vs. Ctrl; ⁺ p < 0.05 vs. MG; ^# p < 0.05 vs. PA; ^& p < 0.05 vs. LPS.