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. 2020 Sep 27;9(10):924. doi: 10.3390/antiox9100924

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic depiction of the protective mechanisms of magnolol (MG) in tyloxapol- and palmitic acid-induced NAFLD. MG activates autophagy by upregulation of ATG5-12, ATG7, Beclin1, and LC3B and reduction of p62/SQSTM1 and p-mTOR expression, which results in the activation of antioxidant Nrf2/HO-1 signaling, thereby suppressing tyloxapol and palmitic acid (PA)-induced hepatic steatosis and inflammation. In addition, MG inhibits hyperlipidemia through downregulation of SREBP-1c, as well as ROS and NLRP3 inflammasome activation.