Figure 8.

Mutant zebrafish retinas have subretinal deposits and short outer segments. Wild-type and mutant retina sections, stained with azure blue (A,B) or hematoxylin and eosin (H&E) (C,D). Deposits can be observed in the 11-month-old mutant azure blue-stained (B) sections between the photoreceptor outer segments and retinal pigment epithelium (arrowheads). H&E-stained sections of 12-month-old mutant retinas (D) show similar accumulations (arrowhead); however, the material that had filled the deposits was stripped from the tissue during processing. rp1l1 mutant retinas have shorter outer segments and thinner outer nuclear layers (D). No deposits were observed in the wild-type retinas (A,C).