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Schematics showing B-cell maturation antigen (BCMA) protein. BCMA is a type III transmembrane protein with no signal sequence at the amino-terminus. Extracellular domain (ECD) of BCMA comprises of 54 amino acids and shed as soluble BCMA (sBCMA) after cleaved by γ-secretase. The transmembrane domain (TM) and the intracellular domain (ICD) of BCMA contain 23 and 107 amino acid residues, respectively.
