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All ubiquitin-like proteins contain one or more structurally near-identical ubiquitin-like folds. The figure represents the individual and aligned structures of ubiquitin (PDB 1ubq), NEDD8 (PDB 2ko3), SUMO-1 (PDB 2n1v), SUMO-2 (PDB 1WM3), SUMO-3 (PDB 1u4a), and ISG15 (PDB 1Z2M). The dashed circles indicate the two ubiquitin-like domains (UBL1 and UBL2) of ISG15.
