Figure 4:

Automatic detection and analysis of important metastable states. A heat-map showing the largest contributions to JS_pops clearly identifies regions of conformational space coinciding with metastable states whose populations are most affected by sequence mutations. Contact maps show computed Bayes Factors for all contacts within selected macrostates. Contacts with large Bayes Factor values are those that uniquely define each macrostate. In all cases, computed Bayes Factors recapitulate the important inter-residue contacts otherwise found by visual inspection (see Figure 3).