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. 2020 Oct 10;42:101097. doi: 10.1016/j.molmet.2020.101097

Figure 1.

Figure 1

BAT from the db/db mice showed inflammatory features and insulin resistance. (A) Representative Western blotting and quantification of STAT3, IKKα/β, JNK, and p38 MAPK phosphorylation in BAT from the db+ and db/db mice (n = 4–8 mice/group). (B) Tlr4, Il6, and Nos2 mRNA expression in BAT (n = 3–7 mice/group). (C) Representative Western blotting and quantification of UCP-1 protein levels in BAT (n = 4–7 mice/group). (D) Representative Western blotting and quantification of IR and AKT phosphorylation in BAT (n = 2–6 mice/group). (E) Pattern of IR isoforms and quantification of the IRA/IRB ratio (n = 7–10 mice/group). Data are expressed as mean ± SEM. The statistical analysis was conducted with the Mann–Whitney U test. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001.