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H3K27M is the major oncogenic driver in pediatric high-grade gliomas (pHGG). (A) The polycomb repressive complex 2 (PRC2) complex mediates the di- and trimethylation of H3K27 in healthy brains. (B) The H3K27M mutation in diffuse midline gliomas (DMG) leads to global loss of di- and trimethylation of histone H3K27 (H3K27me2 and H3K27me3) by inactivating the PRC2 complex.
