Mutations |
Tumor suppressor protein p53 (TP53) |
Mutations |
ATRX chromatin remodeler (ATRX) |
Mutations |
Neurofibromin 1 (NF1) |
Mutations |
Protein phosphatase magnesium-dependent 1 delta (PPM1D) |
Mutations |
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) |
Promoter mutations |
Telomerase reverse transcriptase (TERT) |
Gene fusions |
Neurotrophic receptor tyrosine kinase (NTRK) |
Upregulation |
Paired box 3 (PAX3) |
Upregulation |
Interleukin-13 receptor subunit alpha-2 (IL-13RA2) |
Upregulation |
Poly(ADP-ribose) polymerase 1 (PARP1) |
Deletions |
Phosphatase and tensin homolog (PTEN) |
Amplification |
Cyclin D1/2/3 (CCND1/2/3) |
Amplification |
Cyclin-dependent kinase 4/6 (CDK4/6) |
Amplification |
MET proto-oncogene receptor tyrosine kinase (MET) |