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. 2020 Sep 30;12(10):2813. doi: 10.3390/cancers12102813

Table 1.

Concurrent mutations in the H3 K27M subtype [8,9].

Alteration Gene
Mutations Tumor suppressor protein p53 (TP53)
Mutations ATRX chromatin remodeler (ATRX)
Mutations Neurofibromin 1 (NF1)
Mutations Protein phosphatase magnesium-dependent 1 delta (PPM1D)
Mutations Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA)
Promoter mutations Telomerase reverse transcriptase (TERT)
Gene fusions Neurotrophic receptor tyrosine kinase (NTRK)
Upregulation Paired box 3 (PAX3)
Upregulation Interleukin-13 receptor subunit alpha-2 (IL-13RA2)
Upregulation Poly(ADP-ribose) polymerase 1 (PARP1)
Deletions Phosphatase and tensin homolog (PTEN)
Amplification Cyclin D1/2/3 (CCND1/2/3)
Amplification Cyclin-dependent kinase 4/6 (CDK4/6)
Amplification MET proto-oncogene receptor tyrosine kinase (MET)