Table 1.
IC50 values of excipients in the tested cells. IC50 values on WM164, WM1366, D24, and HaCaT cell lines after 60 min of incubation. All values are expressed in mean concentration of excipients (v/v %) with 95% confidence interval indicated in brackets (n = 5). IC50 values above 100% v/v (%) were considered as not converged. (>Max Conc.; not reaching the sensitive range for the applied concentrations).
| Excipients | IC50 (v/v %) | ||||
|---|---|---|---|---|---|
| WM164 | WM1366 | D24 | HaCaT | Fibroblast | |
| PG | >Max Conc. | >Max Conc. | 14.74 (very wide) |
>Max Conc. | 52.13 (very wide) |
| Labrasol® | 0.04 (0.034–0.058) |
0.11 (0.06–0.21) |
0.03 (0.02–0.06 |
0.04 (0.03–0.04) |
0.08 (0.06–0.13) |
| Transcutol® | ~5.6 (very wide) |
>Max Conc. | 4.55 (3.1-8.2) |
5.75 (very wide) |
>Max Conc. |
| Labrafac® | >Max Conc. | >Max Conc. | 92.16 (very wide) |
6.35 (4.03-8.02) |
>Max Conc. |
| SEME–PG | 0.22 (0.18–0.27) |
0.37 (0.25–0.52) |
0.15 (0.09–0.23) |
0.22 (0.17–0.27) |
0.34 (0.25–0.45) |
| SEME + PG | 0.21 (0.13–0.29) |
0.30 (0.21–0.45) |
0.18 (0.11–0.28) |
0.18 (0.14–0.22) |
0.39 (0.28–0.53) |