Table 1.
Clinical characteristics of the nine included clinical studies of head and neck cancer and chemotherapeutic nanoformulations.
| Patient Characteristics | n |
|---|---|
| Mean age | 59.23 (range 25–87) years |
| Total patients recruited | 229 (range 7–60) |
| Number of patients analyzed | 216 (94.3%) |
| Gender | |
| Male | 179 (78.17%) |
| Female | 50 (21.83%) |
| Previously treated | |
| Yes | 88 (37.9%) |
| No | 141 (62.1%) |
| Tumor Size * | |
| T1 + T2 | 11 (7.43%) |
| T3 + T4 | 137 (92.57%) |
| Lymph nodes metastasis * | |
| Positive | 108 (72.48%) |
| Negative | 41 (27.52%) |
| Distant metastasis * | |
| Yes | 19 (10.86%) |
| No | 156 (89.14%) |
| Died of disease * | |
| Yes | 61 (44.20%) |
| No | 77 (55.80%) |
| Tumor Location | |
| Oral cavity | 97 (41.99%) |
| Larynx | 43 (18.62%) |
| Oropharynx | 38 (16.45%) |
| Hypopharynx | 28 (12.12%) |
| Maxilary sinus | 9 (3.89%) |
| Others | 16 (6.92%) |
* Only reported data were recorded.