Table 1.

Comparison of risk allele frequency between cancer-free families (CFFs) and gnomAD for breast, colorectal, and prostate cancers.

Cancer	SNPID	Gene	Risk Allele	Frequency		OR	95% CI		p 1
				GnomAD	CFF
BC	rs10474352	ARRDC3	C	0.83	0.74	0.56	0.36	0.87	0.0097
	rs16886181	MAP3K1	C	0.17	0.08	0.41	0.20	0.85	0.0165
	rs206966	RP1-166H1.2	T	0.17	0.25	1.67	1.07	2.61	0.0248
	rs2992756	KLHDC7A	T	0.49	0.37	0.62	0.41	0.93	0.0197
	rs653465	SLC4A7	C	0.47	0.57	1.48	1.00	2.20	0.0489
	rs7072776	DNAJC1	A	0.28	0.19	0.58	0.35	0.96	0.0348
	rs889312	MAP3K1	C	0.29	0.18	0.53	0.32	0.89	0.0154
CRC	rs17816465	GREM1	A	0.20	0.10	0.43	0.23	0.84	0.0125
PC	rs10460109	TSHZ1	T	0.42	0.56	1.72	1.16	2.55	0.0067
	rs3850699	TRIM8	A	0.68	0.56	0.6	0.41	0.89	0.0110
	rs28607662	TCF4	C	0.09	0.17	1.96	1.16	3.31	0.0118
	rs2066827	CDKN1B	T	0.75	0.86	2.05	1.17	3.61	0.0125
	rs2680708	RNF43	G	0.60	0.48	0.62	0.42	0.91	0.0153
	rs33984059	RFX7	A	0.98	0.94	0.37	0.16	0.85	0.0193
	rs12155172	LINC01162	A	0.24	0.33	1.62	1.07	2.45	0.0216
	rs6465657	LMTK2	C	0.46	0.57	1.56	1.05	2.31	0.0265
	rs12543663	PCAT1	C	0.31	0.41	1.56	1.05	2.32	0.0270
	rs9364554	SLC22A3	T	0.27	0.19	0.60	0.37	1.00	0.0478

¹p-value for Bonferroni adjusted significance level: breast cancer (BC), 0.05/106 = 0.0005; colorectal cancer (CRC), 0.05/81 = 0.0006; prostate cancer (PC), 0.05/105 = 0.0005; OR: odds ratio; 95%CI: 95% confidence interval; SNPID, SNP identification number; p: p-value; bold values indicate statistical significance at p < 0.05.