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. Author manuscript; available in PMC: 2021 Apr 22.
Published in final edited form as: N Engl J Med. 2020 Oct 22;383(17):1624–1634. doi: 10.1056/NEJMoa2012047

Figure 1. Change in Total Symptom Score.

Figure 1.

Shown is the least-squares mean percentage change from baseline in total symptom score over time. The total symptom score was based on a daily patient-reported outcome questionnaire. The questionnaire assessed eight individual symptoms (each on a scale of 0 to 10, combining to form the total symptom score): abdominal pain, nausea, vomiting, early satiety, loss of appetite, abdominal cramping, bloating, and diarrhea. The total symptom score ranges from 0 to 80, with higher scores indicating greater symptom severity. I bars indicate the standard error.