Table 1.

Summary of studies.

Experimental Model	Species	Delivery Method	Formulation	Dose (mg/kg/day)	References
Sciatic nerve crush	SD Rat	local (osmotic pumps), 28 days	Curcumin	0.2	[34]
Oxaliplatin-induced neuropathies	SD Rat	oral gavage, 28 days	Curcumin	12.5, 25, and 50	[39]
Oxaliplatin- and cisplatin-induced neuropathies	Wistar Rat	i.p., 32 days	Curcumin	10	[40]
Cisplatin-induced neuropathy	Wistar Rat	oral, 35 days	Curcumin	200	[41]
Vincristine-induced neuropathy	Swiss Mouse	oral, 14 days	Curcumin	30 to 60	[42]
Vincristine-induced neuropathy	Wistar Rat	oral, 14 days	Tetrahydrocurcumin	40 and 80	[43]
Diabetic peripheral neuropathy	SD Rat	i.p., acute and chronic (days 7 to 21)	Curcumin	50	[44]
Diabetic peripheral neuropathy	Wistar Rat	oral, 6 weeks	Curcumin	50 or 100	[45]
Diabetic peripheral neuropathy	SD Rat	i.p., 14 days	Curcumin	200	[46]
Diabetic peripheral neuropathy	SD Rat	oral, 35 days	Curcumin	100	[47]
Diabetic peripheral neuropathy	SD Rat	oral, 28 days	Curcumin	60	[48]
Diabetic peripheral neuropathy	Laka Mouse	oral, 28 days	Curcumin	15 to 60	[49]
Diabetic peripheral neuropathy	SPF Rat	oral, 5 days	Curcumin derivative J147	10 to 100 µM	[50]
Diabetic peripheral neuropathy	SD Rat	oral, 14 days	Nano-emulsified curcumin	30 to 300	[51]
Diabetic peripheral neuropathy	SD Rat	i.v., 2 injections (week 7 and 8)	Nanoparticle-encapsulated curcumin	16	[52]
Sciatic nerve chronic constriction injury	SD Rat	i.p., 7 days	Curcumin	20, 40 and 60	[53]
Postoperative pain (surgical paw incision)	SD Rat	p.o., acute	Curcumin	10 to 40	[54]
Sciatic nerve chronic constriction injury	SD Rat	oral, 7 days	Curcumin	50	[55]
Sciatic nerve chronic constriction injury	Wistar Rat	i.p., 1 week	Curcumin	12.5, 25, and 50	[56]
Sciatic nerve chronic constriction injury	C57BL/6J Mice	p.o., 3 weeks	Curcumin	5, 15 or 45	[57]
Spinal nerve ligation	Wistar Rat	Intrathecal and p.o.	Curcumin	i.t. 30 to 300 μg / p.o. 10 to 310	[58]
Sciatic nerve section	BALB/c Mouse	i.p., twice daily for 7 days	Curcumin	30 to 120 mg/kg	[59]
Brachial plexus avulsion	SD Rat	i.p., 28 days	Curcumin	60	[60]
Alcohol-induced neuropathy	Wistar Rat	oral, 70 days	Curcumin	20 to 80	[61]
Alcohol-induced neuropathy	Wistar Rat	i.p., 63 days	Curcumin	60	[62]
Opioid-induced hyperalgesia	C57BL/6J Mice	i.p., 6 days	Curcumin	50	[63]
HIV-gp120-induced neuropathic pain	SD Rat	i.v., 3 injections (days 7, 10 and 13)	Nanoparticle-encapsulated curcumin	4	[64]
Complete Freund’s adjuvant induced neuropathic pain	Charles-Foster Rat	i.p., acute	Curcumin	100	[65]
Sciatic nerve crush in diabetic condition	SD Rat	i.p., 28 days	Curcumin	50 to 300	[66]
Diabetic peripheral neuropathy	Swiss Mouse	oral gavage, twice daily 20 weeks	Curcumin derivative J147	10 to 50	[67]
Sciatic nerve crush	Wistar Rat	oral, 28 days	Curcumin	100	[68]
Sciatic nerve excision	Wistar Rat	local (nerve conducts)	Curcumin	10 µL at 5 mg/mL	[69]
Hereditary peripheral neuropahty (CMT1A)	Mouse (Tr-J)	oral, 90 days	Curcumin	100	[70]
Hereditary peripheral neuropahty (CMT1A)	Mouse (Tr-J)	oral, 90 days	Curcumin	100	[71]
Hereditary peripheral neuropahty (CMT1A)	Rat SD (PMP22)	i.p., 8 weeks	Curcumin–cyclodextrin/cellulose Nanocrystals	0.2	[72]
Hereditary peripheral neuropahty (CMT1B)	Mouse (R98C)	oral, 39 days	Curcumin	100	[73]
Sciatic nerve amputation	BALB/c Mouse	oral, 7 days	Curcumin	20 to 40	[74]
Sciatic nerve chronic constriction injury	SD Rat	i.p., 14 days	Curcumin	100	[75]
Sciatic nerve crush	SD Rat	oral, 28 days	Curcumin	100	[76]
Sciatic nerve crush	Wistar Rat	i.p., 4 weeks	Curcumin	100	[77]
Sciatic nerve crush	SD Rat	i.p., 28 days	Curcumin	100	[78]
Sciatic nerve crush	SD Rat	i.p., 60 days	Curcumin	100	[79]
Sciatic nerve transection	Wistar Rat	i.p., 28 days	Curcumin	100	[80]