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. 2020 Oct 8;10(10):1424. doi: 10.3390/biom10101424

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Pacemaking activity in lymphatic vessels from control (C57BL/6J WT and Cx45^fx/fx) and smooth-muscle Cx45-deficient (Smmhc-CreER^T2;Cx45^fx/fx) mice under control intraluminal pressure (P_upstream = P_downstream = 2 cmH₂O): (A,C) STMs of contractions of popliteal lymphatic vessels recorded over 15 minutes from control and Cx45-deficient animals. Vessel images are aligned to the right sides of the two-dimensional maps; here, valves are indicated with dark arrows. Pacemaking sites are represented by open circles. (B,D) Pacemaking site switching determined after comparing where consecutive contractions were initiated. Comparison is performed one-by-one for all contractions in the STMs shown in A and C. Switching probability (P_Switch) is displayed for each given example.