Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 8;10(10):1424. doi: 10.3390/biom10101424

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Pacemaking activity in lymphatic vessels from control (C57BL/6J WT and Cx45^fx/fx) and LMC Cx45-deficient (Smmhc-CreER^T2; Cx45^fx/fx) mice under differentially increased downstream (downstream) intraluminal pressure (P_downstream>P_upstream): (A,C) STMs of contractions of popliteal lymphatic vessels recorded over 15 minutes from control and Cx45-deficient animals. Different combinations of various upstream–downstream pressure levels (denoted as P_u and P_d respectively) were tested over periods of 5 minutes each. Vessel images are aligned to the right sides of the two-dimensional maps (dark arrows indicate valve location). Pacemaking sites are represented by open circles; (B,D) Pacemaking site switching determined after comparing where consecutive contractions were initiated. Comparison is performed one-by-one for all contractions in the STMs shown in A and C. Switching probability (P_Switch) is displayed for each given example and for each given differential pressure level.