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. 2020 Oct 10;8(10):1560. doi: 10.3390/microorganisms8101560

Figure 3.

Figure 3

ROC curves for LNR and MNR to predict in-hospital mortality at admission in patients with severe Covid-19. (A) For LNR, the best cut-off point to predict in-hospital death was ≤ 0.088 with AUC of 0.832 (95% CI, 0.701–0.922), sensitivity of 85.00%, specificity of 74.19%, Youden index of 0.5919 (95% CI 0.3380–0.7387), RR of 5.8933 (95% CI, 1.9661–17.6652), and OR of 16.2917 (95% CI, 3.7550–70.6837). (B) For NMR, the best cut-off point to predict in-hospital death was ≥ 17.75 with AUC of 0.890 (95% CI, 0.768–0.962), sensitivity of 89.47%, specificity of 80.00%, Youden index of 0.6947 (95% CI, 0.4349–0.8333), RR of 8.8542 (95% CI, 2.2864–34.2878), and OR of 27.9286 (95% CI, 5.1435–151.6497). LNR resulted of dividing the total lymphocyte count by the total neutrophil count. NMR resulted of dividing the total neutrophil count by the total monocyte count. Statistical analyses were performed by means of the MDCalc Software (New York, NY 10003, USA) and the IBM SPSS Statistics version 26.0 (IBM, Armonk, NY, USA). Differences were considered significant when p < 0.05. LNR, Lymphocyte-to-neutrophil ratio; NMR, neutrophil-to-monocyte ratio; ROC, Receiver Operating Characteristic curves; AUC, area under the ROC curve; CI, confidence interval; RR, relative risk; OR, Odd ratio.