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(a) Physiologically based pharmacokinetic model workflow. (b) Schematic representation of selegiline disposition along with Methamphetamine and Desmethyl Selegiline as primary metabolites and Amphetamine as a secondary metabolite. Transdermal absorption of selegiline was mechanistically modeled through the Multi-Phase Multi-Layer Mechanistic Dermal Absorption (MPML-MechDermA) model. Fm represents the fraction metabolized and Fe represents the fraction excreted unchanged in urine.
