Table 3.
Hepatic and renal clearance of selegiline and its metabolites in different populations.
| Population | Moiety | Hepatic Intrinsic Clearance (L/h) | Cardiac Output (L/h) | Hepatic Blood Flow (L/h) | Fraction Unbound (fu) | Renal Function a | Hepatic Clearance (L/h) | Renal Clearance (L/h) |
|---|---|---|---|---|---|---|---|---|
| Healthy | SEL | 24217.92 | 350.19 | 89.30 | 0.10 | 0.99 | 86.11 | 0.34 |
| MAP | 27.70 | 350.19 | 1.00 | 21.14 | 8.6526 | |||
| DMS | 125.44 | 350.19 | 0.47 | 35.36 | 0.9504 | |||
| AMP | 24.745 | 350.19 | 0.84 | 16.79 | 7.9596 | |||
| SRI | SEL | 8221.1 | 268.79 | 71.82 | 0.10 | 0.16 | 66.19 | 0.05 |
| MAP | 8.56 | 268.79 | 1.00 | 7.65 | 1.37 | |||
| DMS | 45.31 | 268.79 | 0.55 | 18.40 | 0.15 | |||
| AMP | 36.29 | 268.79 | 0.87 | 22.01 | 1.26 | |||
| CP-C | SEL | 2109.18 | 299.67 | 70.88 | 0.14 | 0.47 | 57.05 | 0.16 |
| MAP | 1.45 | 299.67 | 1.00 | 1.42 | 4.05 | |||
| DMS | 37.62 | 299.67 | 0.63 | 17.66 | 0.45 | |||
| AMP | 30.11 | 299.67 | 0.91 | 19.70 | 3.73 | |||
| Adolescents | SEL | 20147.64 | 333.70 | 89.59 | 0.10 | 1.05 | 85.88 | 0.36 |
| MAP | 20.89 | 333.70 | 1.00 | 16.94 | 9.11 | |||
| DMS | 95.42 | 333.70 | 0.48 | 30.37 | 1.00 | |||
| AMP | 17.05 | 333.70 | 0.84 | 12.40 | 8.38 |
SEL: Selegiline; MAP: Methamphetamine; DMS: Desmethyl Selegiline; AMP: Amphetamine. a Ratio of glomerular filtration rate (GFR) in a specific population compared to that of a normal GFR value (130 mL/min/1.73 m2 in males and 120 mL/min/1.73 m2 in females).