Figure 2.

Comparison of 26 primary infected sera samples to determine population-wide antibody responses. Sequence analysis among the 26 serum samples were then combined to compare the number of study subjects selecting for specific regions at a pre-determined fold cutoff (>100-fold enrichment compared to the starting library) of envelope (E) polypeptide (A), or non-structural protein 1 (NS1) polypeptide (B). Red boxes represent regions selected by more than 75% of the serum samples. Arrows indicate other regions that were selected by ~50% of the study subjects. (A) E protein in domain II (arrow a), domain III (arrow b and c), and the juxtamembrane stem region (arrow d). (B) NS1 56–71 arrow a, 154–170 arrow b, and 193–204 arrow c. The green box indicates the previously described wing domain (WD).