Figure 4.

Individual amino acid selection for the NS1 wing domain. (A) Patterns of patient selection of amino acids of the wing domain of the NS1 protein were analyzed for each individual amino acid position. Patients selecting for a specific amino acid were filled in (black), and if no selection was seen for the amino acid position, the box remained unfilled. Amino acids that are conserved among all 4 serotypes of DENV are written in red along the top of the table. The regions that correlate to the wing domain have been highlighted by a blue box. (B) NS1 wing domain epitope is highlighted on the structure of the NS1 dimer in red (PDB: 4O6B). The wing domain is unresolved in the structure and is indicated by dotted red lines.