Skip to main content
. 2020 Sep 25;10(10):1365. doi: 10.3390/biom10101365

Figure 1.

Figure 1

Relevance of the nuclear factor erythroid 2 (NF-E2) p45-related factor 2 (NRF2) pathway in colorectal tumours in vivo. (A) Bioinformatic analysis of the expression of various NRF2 target genes in normal and tumour tissues. The activity of NRF2 in colon (upper row) and rectal (lower row) cancers (T) and normal (N) tissues of the TCGA project was assessed through the expression of the NRF2 target genes NQO1 (left) and through the combined score from the expression of NQO1, GPX2, TXNRD1, GCLC and GCLM (right). p: p-value of the Welch’s t-test. (B) NQO1 expression in matched normal and tumour colorectal tissue quantified using real-time PCR. Figures show the combined data (upper panel) or individual patients (lower panel). The data were normalised using β-actin as an internal control. Data represent means ± SD (n = 9). The differences between the tumour and the normal tissue for NQO1 were statistically significant (paired t-test analysis) (* p = 0.0401). (C) Kaplan-Meier plots showing differential cancer-specific survival for colorectal patients with high or low nuclear NRF2 levels (p = 0.041).