Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 29;12(10):931. doi: 10.3390/pharmaceutics12100931

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Hyaluronan nanoparticles improve plaque stability in atherosclerotic mice. (a) Representative images of aortic roots from mice that received either PBS (control, left image panel), HA-nanoparticles (NPs) (middle image panel), or free HA (right image panel) during a 12-week high-fat feeding period. The sections were stained with hematoxylin and eosin (H&E), macrophage-specific antibody (MAC-3), or Sirius red (collagen). Scale bar in the upper right image applies to all H&E-stained sections. Bar charts display mean plaque area (top), percentage of plaque area containing macrophages (middle), and collagen (bottom) in the aforementioned treatment groups; (b) Flow cytometric analysis of aortic arches of treated mice. The left panel shows representative cell scatter plots and histograms obtained for control (upper panel) and HA-NP-treated mouse (lower panel). The immune cells are defined as CD45-positive cells. The bar chart compares the total immune cell count in control, HA-NP-treated, and free HA-treated mice. In all bar charts, the symbol “*” indicates the significant difference at p < 0.05. Adapted with permission from [67]. Copyright 2017, American Chemical Society.