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Schematic drawing of protein constructs expressed in human cells. The full-length fibroblast growth factor receptor-like protein 1 (FGFRL1) is indicated at the top with three Ig domains, a transmembrane helix (TM) and a short, histidine-rich intracellular domain (His). The entire extracellular domain (Ig123), all combinations containing two Ig domains (Ig12, Ig23, Ig13) as well as all individual Ig domains (Ig1, Ig2, Ig3) were expressed in HEK293 cells.
