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β-Arrestin-2: JNK3 scaffold. β-Arrestin-2 specifically associates with the JNK3, MKK7/4 and ASK1. Inactive-JNK3 binds β-arrestin-2 close to the MKK7/4 bond-site, facilitating full JNK3 activation. P-JNK3 loses its affinity to the scaffold and, by detaching from it, allows the binding of other inactive JNK3.
