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. 2020 Oct 11;12(10):2923. doi: 10.3390/cancers12102923

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

UM-EVs and NCM-EVs carried different sets of proteins. Venn diagram analyses. (A) The majority of proteins isolated from EVs derived from UM cells and NCMs were shared with data published in Vesiclepedia database. (B) NCM-EVs and primary UM-EVs shared 708 proteins, while 1 and 1433 proteins were exclusively present in NCM-EVs and primary UM-EVs, respectively. (C) Based on their protein cargo, primary UM-EVs clustered differently from NCM-EVs. A total of 20 to 265 proteins were exclusively shared between NCM-EVs and primary UM-EVs, while 287 to 1074 proteins were exclusively shared between EVs isolated from the different primary UM lines.