Figure 3.

Transcription factor motif analysis of BRAF inhibitor resistance in cellular models of malignant melanoma [141]. Red indicates transcription factors relevant to upregulated genes and blue indicates transcription factors relevant to downregulated genes. (a) Schematic representation of differentially expressed genes in a drug resistance model and transcription factor motifs associated with regulated target genes. Upregulated factors are depicted in red and downregulated factors in blue. (b) Hierarchical transcription factor network with master regulators on top and downstream targets at bottom. Sets of transcription factor target genes are identified in enrichment analysis based on sequence motifs. (c) Hierarchical network model illustrates how therapy resistance in cancer selects for specific transcriptional master regulators to rewire target genes in effector pathways in a concerted fashion. From Zecena et al. BMC Syst Biol 2018, 12, 33 [141]. Copyright © 2018, Zecena, Tveit, Wang, Farhat, Panchal, Liu, Singh, Sanghera, Bainiwal, Teo, Meyskens, Liu-Smith, and Filipp.