Figure 12.

A simplified representation of the canonical and non-canonical Wnt signaling pathway. Small Rho GTPases are involved only in the non-canonical Wnt pathways. Wnt–Wnt family member; Fzd—Fizzled class receptor; Dvl—disheveled segment polarity protein; Rac1—Rac family small GTPase 1; Rho A—Ras homolog family member A; cdc42—cell division cycle 42; JNK—c-Jun N-terminal kinase; ROCK—Rho-associated coiled-coil containing protein kinase; PKC—protein kinase C; c-jun—Jun proto-oncogene; GSK3—glycogen synthase kinase 3; LRP—low-density-lipoprotein (LDL) receptor-related protein; Tcf—transcription factor.