Table 1.
Baseline characteristics of the DIRECT PLUS participants across sex-specific vitamin B12 tertiles.
| Entire n = 294 |
Lowest Tertile n = 99 |
Intermediate Tertile n = 98 |
Highest Tertile n = 97 |
p Between Tertiles 1 | p Between Extreme Tertiles 2 | |
|---|---|---|---|---|---|---|
| Vitamin B12, pg/mL | 420.4 ± 187 | 261.2 ± 46.1 | 385.7 ± 37.9 | 618.1 ±1 92.8 | - | - |
| Age, years | 51.1 ± 10.5 | 51.9 ± 9.6 | 49.7 ± 10.5 | 51.5 ± 11.4 | 0.25 | 0.54 |
| Men, number | 259 | 87 | 86 | 86 | 0.98 | - |
| BMI, kg/m2 | 31.3 ± 4.0 | 31.3 ± 4.3 | 31.3 ± 3.9 | 31.2 ± 3.7 | 0.84 | 0.87 |
| WC, cm | 109.7 ± 9.5 | 110.1 ± 9.7 | 109.6 ± 10.5 | 109.4 ± 8.1 | 0.67 | 0.93 |
| Fasting glucose, mg/dL | 101.9 ± 17.1 | 104.0 ± 19.5 | 101.2 ± 14.7 | 100.6 ± 16.5 | 0.62 | 0.35 |
| Cholesterol, mg/dL | 190.6 ± 33.0 | 190.9 ± 29.5 | 190.9 ± 33.8 | 189.8 ± 35.9 | 0.97 | 0.82 |
| HDL-c, mg/dL | 46.0 ± 11.7 | 45.0 ± 12.4 | 46.2 ± 11.3 | 46.7 ± 11.3 | 0.29 | 0.15 |
| LDL-c, mg/dL | 125.7 ± 30.1 | 125.5 ± 28.6 | 127.0 ± 31.6 | 124.5 ± 32.4 | 0.86 | 0.83 |
| Triglycerides, mg/dL | 146.3 ± 66.8 | 159.4 ± 66.9 | 139.8 ± 60.0 | 139.5 ± 68.8 | 0.02 | 0.01 |
| ALT, U/L | 34.9 ± 16.8 | 34.3 ± 14.4 | 35.4 ± 20.4 | 34.9 ± 15.0 | 0.79 | 0.71 |
| AST, U/L | 25.6 ± 7.7 | 25.5 ± 7.2 | 26.1 ± 8.7 | 25.3 ± 7.3 | 0.90 | 0.74 |
Continuous data presented as means ± SD. Lowest tertile: Men: < = 322.49 pg/mL; Women: < = 318.43 pg/mL. Intermediate tertile: Men: 322.50 pg/mL–439.02 pg/mL; Women: 318.44 pg/mL–478.32 pg/mL. Highest tertile: Men: 439.03 + pg/mL; women: 478.33 + pg/mL. 1 tested using ANOVA/Kruskal-Wallis. 2 tested using T-test/Mann-Whitney. ALT, alanine transaminase; AST, aspartate transaminase. BMI, body mass index; HDL-c, high density lipoprotein cholesterol; LDL-c, low density lipoprotein cholesterol; WC, waist circumference.