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. 2020 Oct 13;10(10):725. doi: 10.3390/brainsci10100725

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Tests used to evaluate the endophenotypes stimulation, intoxication, and aversion in humans and rodents. For humans, the Subjective High Assessment Scale (SHAS), Alcohol Sensitivity Questionnaire (ASQ), and Biphasic Alcohol Effects Scale (BAES) evaluate more than one endophenotype. In addition, body sway is used to measure intoxication in humans. For rodents, locomotor stimulation and conditioned taste aversion (CTA) assess stimulation and aversion, respectively, and multiple tests are used to measure intoxication including loss of righting response (LORR), ataxia, and hypothermia.